C
Grade

Dexamethasone

Some PK studies in children have been published, however, no infants were included. CL might be higher in younger patients.

Level 2

PK model including infants or PopPK model without infants

Author Method Number of Patients/Infants(<1yrs) Age(yr), Median(range) Age related findings
Yang (2008) One compartment popPK model 214 / 0 NS (1-18.8) Negative correlation between patient age and CL/F (normalized to BSA). Higher CL in younger patients.
Inaba (2018) One compartment popPK model 409 / 0 NS (1-18) Effect of age on PK was not studied.
Jackson (2019) One compartment popPK model. Allometric scaling of CL for BW. 161 / 0 NS (1.3-18.7) No effect of age on PK.

Level 3

Non-compartmental PK study or PK model without infants

Author Method Number of Patients/Infants(<1yrs) Age(yr), Median(range) Age related findings
Spektor (2008) Non-compartmental pharmacokinetics 25 / 0 4 (1-14) Effect of age was not studied. But t1/2 comparable to data reported in adults.
Kawedia (2012) Not stated 339 / 0 NS CL (L/h/m2) higher in patients less than 10 years old