C
Grade

Idarubicin

Some PK studies in children have been published, however, no infants were included and the effect of age was only studied once. No effect on the PK of idarubicin has been found.

Level 3

Non-compartmental PK study or PK model without infants

Author Method Number of Patients/Infants(<1yrs) Age(yr), Median(range) Age related findings
Tan (1987) Non-compartmental pharmacokinetics (idarubicin, idarubicinol) 7 / 0 NS (1-19) Effect of age was not studied.
Reid (1990) Non-compartmental pharmacokinetics (idarubicin, idarubicinol) 21 / 0 NS (1-21) No effect of age on PK parameters of idarubicin or idarubicinol
Dreyer (2003) Non-compartmental pharmacokinetics (idarubicin, idarubicinol) 14 / 0 7.2 (2.2-19) Effect of age was not studied.