A
Grade
Melphalan
PK studies in children (including infants) have been published. No effect of age on the PK of melphalan has been found.
Level 1
Population PK model including infants
| Author | Method | Number of Patients/Infants(<1yrs) | Age(yr), Median(range) | Age related findings | ||
|---|---|---|---|---|---|---|
| Nath (2007) | Two compartment popPK model. BW, eGFR and previous carboplatin treatment were included as covariate on CL. BW was included as covariate on V. | 59 / NS | NS (0.3-17.6) | No effect of age on PK parameters. BW, creatinine CL important covariates for CL and BW for V. | ||
| Schaiquevich (2012) | Two compartment popPK model. BW was included as covariate on the PK parameters. | 17 / NS | 1.8 (0.6-6.2) | Inter-individual variability partly explained by age, BW and BSA. | ||
| Taich (2014) | Two compartment popPK model. The dose was normalized to BW. | 21 / NS | 1.7 (0.5-6.2) | No additional effect of age on PK parameters that was not explained by BW. |
Level 2
PK model including infants or PopPK model without infants
| Author | Method | Number of Patients/Infants(<1yrs) | Age(yr), Median(range) | Age related findings | ||
|---|---|---|---|---|---|---|
| Vassal (2001) | Two compartment popPK model | 21 / NS | 4.1 (0.7-14.2) | Effect of age on PK not studied. Correlation between age and neutropenia/platelet recovery. Younger age associated with prolonged neutropenia and delayed platelet recovery. | ||
| Mizuno (2018) | Two compartment popPK model. Allometric scaling for BW. eGFR was included as covariate on CL. | 5 / 0 | 5.6 (1.5-16.5) | No effect of age on PK parameters. | ||
| Duong (2019) | Two compartment popPK model. Allometric scaling for BW. | 51 / 0 | 3.5 (1.7-8.3) | No effect of age on the PK parameters after including BW into the covariate model. |
Level 3
Non-compartmental PK study or PK model without infants
| Author | Method | Number of Patients/Infants(<1yrs) | Age(yr), Median(range) | Age related findings | ||
|---|---|---|---|---|---|---|
| Taha (1983) | One compartment PK model | 10 / 0 | 5.5 (2.5-16) | No effect of age on PK parameters | ||
| Ninane (1985) | Two compartment PK model | 9 / 1 | 4.1 (1.1-10) | Effect of age was not studied. | ||
| Ardiet (1986) | Two compartment PK model | 26 / 0 | 12.2 (1.3-57) | No difference in PK between adults in children. But a trend towards lower exposures in children due to shorter half-life. | ||
| Gouyette (1986) | Two compartment PK model | 20 / 0 | 4.4 (1.8-14) | Effect of age was not studied. | ||
| Horowitz (1988) | Non-compartmental pharmacokinetics | 26 / 1 | 11 (<1-21) | Effect of age was not studied. | ||
| Nath (2005) | Non-compartmental pharmacokinetics | 52 / NS | 5.6 (0.3-18) | No additional effect of age on PK parameters that was not explained by BW. | ||
| Zhao (2021) | Non-compartmental pharmacokinetics | 5 / 0 | 5.6 (1.5-16.8) | Effect of age was not studied. |
