C
Grade
Methotrexate (Low Dose)
Some PK studies in children have been published, however, no infants were included and the effect of age was not studied in most of the studies. No effect of age on the PK of methotrexate low dose has been found.
Level 3
Non-compartmental PK study or PK model without infants
| Author | Method | Number of Patients/Infants(<1yrs) | Age(yr), Median(range) | Age related findings | ||
|---|---|---|---|---|---|---|
| Pinkerton (1982) | Non-compartmental pharmacokinetics (MTX p.o. and i.v., plasma MTX concentrations) | 28 / 0 | NS (3-16) | No effect of age on absorption of MTX. | ||
| Sonneveld (1986) | Non-compartmental pharmacokinetics (MTX p.o., plasma MTX concentrations) | 19 / 0 | 6.3 (3-14), mean (range) | Effect of age was not studied. | ||
| Pearson (1987) | Non-compartmental pharmacokinetics (MTX p.o. and i.m., plasma MTX concentrations) | 127 / 0 | NS (1-14) | No effect of age on absorption or CL (L/h/m2) of MTX. | ||
| Balis (1988) | Non-compartmental pharmacokinetics (MTX p.o. and s.c., plasma MTX concentrations) | 8 / 0 | 8 (3-19) | Effect of age was not studied. | ||
| Koren (1989) | Non-compartmental pharmacokinetics (MTX p.o., plasma MTX concentrations) | 16 / 0 | 6.26 (3.75-16.75), mean (range) | A weak correlation between AUC and age was observed. | ||
| Skoglund (1994) | Non-compartmental pharmacokinetics (MTX p.o., plasma MTX concentrations) | 17 / 0 | 7.3 (3-12), mean (range) | Effect of age was not studied. | ||
| Balis (1998) | Non-compartmental pharmacokinetics (MTX p.o., plasma MTX concentrations) | 89 / 0 | 4.6 (1.1-17.3) | No effect of age on CL (mL/min/m2) of MTX. |
