Some PK studies in children have been published, however, no infants were included. No effect of age on the PK of prednisolone has been found.
Author | Method | Number of Patients/Infants(<1yrs) | Age(yr), Median(range) | Age related findings | ||
---|---|---|---|---|---|---|
Sassen (2021) | One compartment popPK model. Allometric scaling for BW. Plasma protein binding of prednisolone and the ratio of prednisolone/prednisone was included as covariate. | 124 / 1 (Fig. 3) | 6.2 (0.4–17.7) | The plasma protein binding of prednisolone to corticosteroid-binding globulin was associated with patient age. The estimated corticosteroid-binding globulin concentration decreased with age. No correlation between CL of unbound prednisolone (corrected for BSA) and age was observed. |
Author | Method | Number of Patients/Infants(<1yrs) | Age(yr), Median(range) | Age related findings | ||
---|---|---|---|---|---|---|
Petersen (2003) | Two compartment popPK model. BSA was included as covariate on CL. BW was included as covariate on V1 and V2. | 23 / 0 | 5.4 (2.4-15.2) | No additional effect of age on PK parameters that was not explained by BSA or BW. |
Author | Method | Number of Patients/Infants(<1yrs) | Age(yr), Median(range) | Age related findings | ||
---|---|---|---|---|---|---|
Choonara (1989) | Non-compartmental pharmacokinetics | 6 / 0 | 4.75 (2.8-12.4) | No effect of age on PK in these 6 patients. But values here for CL (mL/min/kg) are slightly higher than those reported in studies with older children. | ||
Hill (1990) | Non-compartmental pharmacokinetics | 43 / 0 | 10 (2-50), mean (range) | Significant negative correlation between BSA-normalized CL and age. Children <12 years old had higher CL than older children and adults. |